Poly(ADP-ribose) drives pathologic α-synuclein

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Betulinic acid (16) (Figure 19.4) is a pentacyclic triterpenoid with antiretroviral, antimalarial, and anti-inflammatory and anticancer properties [56].Its anticancer actions involve the inhibition of topoisomerase [56].Compound 13 has been isolated in several African medicinal plants among which were Diospyros canaliculata (Ebenaceae) [50], and Irvingia gabonensis (Ixonanthaceae) [52] as well ...read more


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A new disulfide‐linked dimer of a single‐chain antibody

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Quanta Magazine

As previously described , a single intrastriatal injection of α-syn PFF leads to an approximate 50% loss of DA neurons 6 months after the injection in wild-type (WT) mice (Fig. 3, B and C). In contrast, a single intrastriatal injection of α-syn PFF into PARP-1 KO mice failed to induce DA cell loss (Fig. 3, B and C). ...read more


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Endocrine Pharmacology - ScienceDirect

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The assertion is also made that Denis Papin (q.v.) in 1707 propelled a boat by steam on the River Fulda. Papin invented the safety valve and a single-acting steam cylinder pump, and made various improvements in steam pumps, but it does not appear that he ever built what might be … ...read more


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